Description
Product Characteristics:
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
Subcellular location: Cytoplasm
Synonyms: NESH, SSH3BP3, ABI gene family member 3, New molecule including SH3, ABI3
Target Information: This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. [provided by RefSeq, Sep 2008]